Description
MAP kinase kinase 1 (MEK1) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation {14328,14329}. This pathway also plays a key role in synaptic plasticity in the brain {14327}. Activated MEK1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase {14331,14332,14543}. Conversely, there also appears to be a feedback phosphorylation of MEK1 by MAP kinase. The sites on MEK1 that are phosphorylated by MAP kinase are Thr292 and Thr386 {14330}.
Synonyms: MAP Kinase Kinase 1|MAPKK1|Mitogen-activated Protein Kinase Kinase 1
Immunogen: phosphopeptide corresponding to amino acid residues surrounding the Phospho-Thr386 of human MEK1
Formulation: Affinity-purified IgG
Isotype:
Applications: WB
Origin: Animal/Rabbit
Stability: 365 days
Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling
