An antimalarial compound; increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg

Mefloquine (hydrochloride) – 100 mg

Brand:
Cayman
CAS:
51773-92-3
Storage:
4
UN-No:
Non-Hazardous - /

Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties.{38380} It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites.{38381} It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis.{38382,38383} Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior.{38383} Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.  

 

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Description

An antimalarial compound; increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively; inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites; A2A receptor antagonist; 5-HT2A and 5-HT2C agonist; has various effects on calcium homeostasis; has effects in mice typically associated with anxiolytic and antidepressant-like behavior

Formal name: rel-αS-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol, monohydrochloride

Synonyms:  NSC 157387|Ro 21-5998/001

Molecular weight: 414.8

CAS: 51773-92-3

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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