A NSAID and COX-2 inhibitor; binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid in vitro (Ki = 10 µM); reduces acetic acid-induced writhing in rats at 30 mg/kg; inhibits DNBC-induced increases in skin thickness in a mouse model of delayed-type hypersensitivity; reduces the antibody response to sheep red blood cells in mice

Mefenamic Acid – 500 mg

Brand:
Cayman
CAS:
61-68-7
Storage:
4
UN-No:
Non-Hazardous - /

Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and a COX-2 inhibitor.{41197} It binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in vitro (Ki = 10 µM). Mefenamic acid (30 mg/kg) reduces acetic acid-induced writhing in rats.{41198} It inhibits increases in skin thickness in a mouse model of delayed-type hypersensitivity induced by dinitrochlorobenzene (DNBC).{41198} Mefenamic acid also reduces the antibody response to sheep red blood cells in mice.  

 

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SKU: 23650 - 500 mg Category:

Description

A NSAID and COX-2 inhibitor; binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid in vitro (Ki = 10 µM); reduces acetic acid-induced writhing in rats at 30 mg/kg; inhibits DNBC-induced increases in skin thickness in a mouse model of delayed-type hypersensitivity; reduces the antibody response to sheep red blood cells in mice

Formal name: 2-[(2,3-dimethylphenyl)amino]-benzoic acid

Synonyms:  C.I. 473|CN 35355|NSC 94437

Molecular weight: 241.3

CAS: 61-68-7

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Pain Research

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