A selective agonist of α2-adrenoceptors (Ki = 1.08 nM vs. 1750 nM for α1-adrenoceptors) that has sedative

Medetomidine (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
86347-15-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Medetomidine is an imidazole derivative that acts as a selective agonist of α2-adrenoceptors (Ki = 1.08 nM vs. 1750 nM for α1-adrenoceptors).{26978,25422} Medetomidine is a mixture of D and L isomers, with the D form, known as dexmedetomidine (Item No. 15581), described as the active form. Through its effect on α2-adrenoceptors, medetomidine has sedative, antinociceptive, analgesic, and hypothermic actions.{26974,26980} Its effects on pain are additive or synergistic with fentanyl-type opioids.{26977,26976} The effects of medetomidine are effectively countered by α2-adrenoceptor antagonists, like atipamezole.{26979} Selective α2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the α2-adrenoceptor agonist.{26980}  

 

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Description

A selective agonist of α2-adrenoceptors (Ki = 1.08 nM vs. 1750 nM for α1-adrenoceptors) that has sedative, antinociceptive, analgesic, and hypothermic actions; additive or synergistic with fentanyl-type opioids in reducing pain; has anesthetic sparing properties

Formal name: 5-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, monohydrochloride

Synonyms:  Domitor®|MPV 785

Molecular weight: 236.7

CAS: 86347-15-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Pain Research

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