Description
A nootropic agent; inhibits norepinephrine reuptake by isolated rat striatal synaptosomes (IC50 = 0.5 mM) and 5-HT reuptake by isolated rat cortical synaptosomes (IC50 = 2.7 mM); increases survival of dopaminergic neurons in a C. elegans psd-1 knockdown model of Parkinson’s disease; reduces rotenone-induced depletion of dopamine and GSH, lipid peroxidation, production of NO, and cortical and cerebral damage, as well as enhances activity of catalase and superoxide dismutase in a rat model of Parkinson’s disease at 100 mg/kg; increases synaptic surface density and reduces age-induced decreases in synaptic numerical density in aged rats at 100 mg/kg; reduces neuronal lipofuscin pigment in the cerebral cortex and hippocampus and improves learning and memory in the T-maze in aged mice
Formal name: 2-(4-chlorophenoxy)-acetic acid, 2-(dimethylamino)ethyl ester, monohydrochloride
Synonyms: Dimethylaminoethyl 4-chlorophenoxyacetate|Methocynal
Molecular weight: 294.2
CAS: 3685-84-5
Purity: ≥98%
Formulation: A solid
