A quinazolinone derivative that selectively inhibits dynamin GTPase activity in yeast and mammalian cells (IC50 = 1-10 μM); prevents apoptosis by inhibiting mitochondrial outer membrane permeabilization

Mdivi 1 – 5 mg

Brand:
Cayman
CAS:
338967-87-6
Storage:
-20
UN-No:
Non-Hazardous - /

Mitochondrial fusion and division proteins function via self assembly to regulate membrane dynamics during various cellular events. For example, the self assembly of dynamin-1, a mitochondrial protein that facilitates endocytosis, with a dynamin related-GTPase (Dnm1 (yeast)/Drp1(mammals)), a mitochondrial protein that functions during mitochondrial division, is thought to regulate apoptosis.{25445} Mdivi 1 is a quinazolinone derivative that selectively inhibits mitochondrial division by blocking dynamin GTPase activity in yeast (IC50 = 1-10 μM) and mammalian cells (IC50 = ~50 μM).{25445} It has been shown to prevent apoptosis by inhibiting mitochondrial outer membrane permeabilization in vivo and to block Bid-activated Bax/Bak-dependent cytochrome c release from mitochondria in vitro.{25445} It has been used to maintain mitochondrial integrity and to prevent cell death in models of pathological conditions including cancer, heart failure, and ischemia and reperfusion injuries.{25446}  

 

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Description

A quinazolinone derivative that selectively inhibits dynamin GTPase activity in yeast and mammalian cells (IC50 = 1-10 μM); prevents apoptosis by inhibiting mitochondrial outer membrane permeabilization

Formal name: 3-(2,4-dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone

Synonyms:  Mitochondrial Division Inhibitor 1

Molecular weight: 353.2

CAS: 338967-87-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|GTPases||Research Area|Cancer|Cell Death||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Heart||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|GTPases||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Cell Biology|Mitochondrial Biology

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