Description
A dual agonist of PPARα and PPARγ; binds to PPARα and PPARγ (Kds = 9.55 and 0.14 μM, respectively); increases transcriptional activity of PPARα and PPARγ in a cell-based luciferase reporter assay at 10 μM; increases expression of PPARα, PPARγ, and RXR, as well as PPARα and PPARγ target genes, in HepG2 cells at 10 μM; increases glucose consumption as well as expression of GLUT2 and GLUT4 in HepG2 and 3T3-L1 cells, respectively, in a concentration-dependent manner; decreases levels of glucose, insulin, free fatty acids, triglycerides, LDL, ALT, and AST in blood and reduces the size and number of hepatic lipid droplets in diabetic db/db mice at 20 mg/kg
Formal name: 5,7-dihydroxy-8-methyl-3-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-4-phenyl-2H-1-benzopyran-2-one
Synonyms:
Molecular weight: 398.4
CAS: 2254605-76-8
Purity: ≥90%
Formulation: A crystalline solid
Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias
