A specialized pro-resolving mediator; accelerates tissue regeneration in planaria at a concentration of 1 and 100 nM; reduces neutrophil infiltration

MCTR3 – 50 µg

Brand:
Cayman
CAS:
1784701-63-8
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Maresin conjugates in tissue regeneration 3 (MCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; Item No. 90310) in macrophages.{29715,33727} DHA is oxidized to maresin 1 (MaR1; Item No. 10878), which is converted to MCTR1 (Item No. 17007) by glutathione S-transferase Mu 4 or leukotriene C4 synthase, then to MCTR2 (Item No. 17008) by γ-glutamyl transferase, and to MCTR3 by dipeptidase.{33713} MCTR3 accelerates tissue regeneration in planaria (1 and 100 nM) approximately as potently as MCTR2 and more potently than MCTR1.{33727} Pretreatment with MCTR3 prior to E. coli administration in mice reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages. When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR3 selectively reduces the amount of the eicosanoids PGD2 (Item No. 12010), PGE2 (Item No. 14010), PGF2α (Item No. 16010), and TXB2 (Item No. 19030) in the exudate.  

 

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Description

A specialized pro-resolving mediator; accelerates tissue regeneration in planaria at a concentration of 1 and 100 nM; reduces neutrophil infiltration, shortens inflammatory resolution, and increases phagocytosis by macrophages; selectively reduces the eicosanoids PGD2, PGE2, PGF2α, and TXB2 in the inflammatory exudate in a mouse model of peritonitis,

Formal name: 13R-[[(2R)-2-amino-2-carboxyethyl]thio]-14S-hydroxy-4Z,7Z,9E,11E,16Z,19Z-docosahexaenoic acid

Synonyms:  13-cysteinyl-14-hydroxy-Docosahexaenoic Acid|Maresin Conjugates in Tissue Regeneration 3|Maresin Sulfido Conjugate 3

Molecular weight: 463.6

CAS: 1784701-63-8

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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