A macrophage-derived SPM that accelerates tissue regeneration (at 1 and 100 nM)

MCTR2 – 25 µg

Brand:
Cayman
CAS:
1784701-62-7
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; Item No. 90310) in macrophages at the site of inflammation.{29715,33727} DHA is oxidized to maresin 1 (MaR1; Item No. 10878), which is converted to MCTR1 (Item No. 17007) by glutathione S-transferase Mu 4 or leukotriene C4 synthase then to MCTR2 by γ-glutamyl transferase.{33713} MCTR2 accelerates tissue regeneration in planaria (1 and 100 nM).{33727} Pretreatment with MCTR2 prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages.{33727} When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR2 selectively reduced the amount of the eicosanoids PGD2 (Item No. 12010) and PGF2α (Item No. 16010) in the exudate.{33727}  

 

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Description

A macrophage-derived SPM that accelerates tissue regeneration (at 1 and 100 nM), reduces neutrophil infiltration, shortens inflammatory resolution, increases phagocytosis at 50 ng/mouse, and reduces eicosanoid formation (at 100 nM)

Formal name: S-[(1R,2E,4E,6Z,9Z)-12-carboxy-1-[(1S,3Z,6Z)-1-hydroxy-3,6-nonadien-1-yl]-2,4,6,9-dodecatetraen-1-yl]-L-cysteinyl-glycine

Synonyms:  13-cysteinylglycinyl-14-hydroxy Docosahexaenoic Acid|Maresin Conjugates in Tissue Regeneration 2|Maresin Sulfido Conjugate 2

Molecular weight: 520.7

CAS: 1784701-62-7

Purity: ≥97%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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