A macrophage-derived SPM that accelerates tissue regeneration (at 1 and 100 nM)

MCTR1 – 50 µg

Brand:
Cayman
CAS:
1784701-61-6
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Maresin conjugates in tissue regeneration 1 (MCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; Item No. 90310) in macrophages at the site of inflammation.{29715,33727} DHA is oxidized to maresin 1 (MaR1; Item No. 10878), which is then converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase.{27629,33713,27956} MCTR1 accelerates tissue regeneration in planaria (1 and 100 nM).{33727} Pretreatment with MCTR1 (50 ng/mouse, i.p.) prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages.{33727} When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR1 reduces the amount of eicosanoids in the exudate.  

 

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Description

A macrophage-derived SPM that accelerates tissue regeneration (at 1 and 100 nM), reduces neutrophil infiltration, shortens inflammatory resolution, increases phagocytosis at 50 ng/mouse, and reduces eicosanoid formation (at 100 nM)

Formal name: L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-12-carboxy-1-[(1S,3Z,6Z)-1-hydroxy-3,6-nonadien-1-yl]-2,4,6,9-dodecatetraen-1-yl]-L-cysteinyl-glycine

Synonyms:  13-glutathionyl-14-hydroxy Docosahexaenoic Acid|Maresin Conjugates in Tissue Regeneration 1|Maresin Sulfido Conjugate 1

Molecular weight: 649.8

CAS: 1784701-61-6

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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