A potent

MCOPPB (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
1108147-88-1
Storage:
-20
UN-No:
Non-Hazardous - /

The nociceptin/orphanin FQ peptide (NOP, ORL1, or OP4) receptor is a member of the opioid family of receptors that integrates the emotional components of anxiety, fear, and stress. MCOPPB is a potent agonist for the NOP receptor (pKi = 10.1, EC50 = 0.39 nM) with 12-, 270-, and >1,000-fold selectivity over the μ-, κ-, and δ-opioid receptors.{22070,22071} In rodents, MCOPPB at 10 mg/kg, p.o. produces potent anxiolytic effects, without inhibiting memory or motor function or inducing sedative side effects.{22070} This product is intended for research purposes only.  

 

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SKU: 12037 - 10 mg Category:

Description

A potent, selective agonist for the nociceptin receptor (pKi = 10.1, EC50 = 0.39 nM); produces potent anxiolytic effects in rodents at 10 mg/kg, p.o. without inhibiting memory or motor function or inducing sedative side effects

Formal name: 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazole, trihydrochloride

Synonyms: 

Molecular weight: 518

CAS: 1108147-88-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety

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