Description
Medium-chain fatty acyl-CoA dehydrogenase (MCAD) is a mitochondrial enzyme that catalyzes the first step in the βoxidation of fatty acids. MCAD expression is induced during periods of fasting, when reliance on fatty acids for energy is increased.{7572,7416} The promoter for MCAD contains a peroxisome proliferator response element (PPRE) and is regulated transcriptionally by peroxisome proliferator-activated receptor alpha (PPARα), a ligand-activated transcription factor involved in the regulation of lipid homeostasis.{7572,7571,4136} Because of this, MCAD expression can be used as a marker to evaluate the in vivo activity of PPARα.{7572,7416} Human MCAD is approximately 87% homologous to porcine and rat MCAD, respectively.{7568,7570} MCAD is expressed in liver, heart, kidney, and skeletal muscle.
Synonyms: ACADM|Medium-chain Fatty Acyl-CoA Dehydrogenase|Medium-chain Specific Acyl-CoA Dehydrogenase mitochondrial
Immunogen: Full length human recombinant MCAD
Formulation: Protein A-purified polyclonal antibody
Isotype:
Applications: WB; other applications not tested
Origin: Animal/Rabbit
Stability: 365 days
Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs
