Description
Mitochondrial antiviral-signaling protein (MAVS) is a mitochondrial membrane-bound adapter protein that initiates antiviral immunity.{46479} MAVS is activated upon viral infection by the dsRNA-sensing receptors RIG-I and MDA5 and by mitochondrial reactive oxygen species (ROS). Upon activation, MAVS polymerizes and binds to TANK-binding kinase 1 (TBK1) and IKKε, which form a signaling platform to activate IFN regulatory factor 3 (IRF3) and NF-ĸB, respectively.{46479,46480} MAVS also mediates recruitment of the NLRP3 inflammasome to the mitochondria and activates caspase-1 to release IL-1β in response to non-crystalline inflammasome activators.{46481} Embryonic fibroblasts, peritoneal and bone marrow-derived macrophages (BMDMs), and conventional, but not plasmacytoid, dendritic cells from Mavs-/- mice exhibit reduced Sendai virus-induced increases in IFN-α and IFN-β secretion.{46482} Serum viral titers are increased and survival is decreased in Mavs-/- mice infected with vesicular stomatitis virus compared with wild-type controls. MAVS-deficient, SLE-prone Fcgr2b-/- mice have decreased serum levels of antinuclear autoantibodies and increased survival compared with MAVS-expressing Fcgr2b-/- mice.{46484} Aggregates of MAVS and plasma levels of IFN-β and the autoantibodies Sm and UN1RNP are increased in peripheral blood mononuclear cells (PBMCs) isolated from patients with systemic lupus erythematosus (SLE).{46483} Cayman’s MAVS Monoclonal Antibody (Clone 7B9) can be used for ELISA, Immunohistochemistry, and Western blot applications. The antibody recognizes MAVS at 56.5 kDa from human samples.
Synonyms: CARD Adapter-Inducing Interferon-β|Interferon-β Promoter Stimulator Protein 1|Mitochondrial Antiviral-Signaling Protein|Virus-Induced Signaling Adapter
Immunogen: Full-length recombinant human MAVS protein
Formulation: 100 µg of protein G-purified antibody
Isotype: IgG2b
Applications: ELISA, IHC, and WB
Origin:
Stability: 365 days
Application|ELISA||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Immunology & Inflammation|Autoimmunity|Lupus||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease|Viral Diseases
