A CXCR4 antagonist (IC50 = 13 nM in a radioligand binding assay); selective for CXCR4 over CCR1

Mavorixafor – 5 mg

Brand:
Cayman
CAS:
558447-26-0
Storage:
-20
UN-No:
Non-Hazardous - /

Mavorixafor is a chemokine (C-X-C motif) receptor 4 (CXCR4) antagonist (IC50 = 13 nM in a radioligand binding assay).{45673} It is selective for CXCR4 over chemokine (C-C motif) receptor 1 (CCR1), CCR2b, CCR4, CCR5, CXCR1, and CXCR2 (IC50s = >10 µM for all). Mavorixafor reduces chemotaxis of CCRF-CEM T cells induced by chemokine (C-X-C motif) ligand 12 (CXCL12; IC50 = 19 nM).{45674} It inhibits fusion of CHO-K1 cells expressing gp120 to P4-P5 MAGI cells with an IC50 value of 1.5 nM. It decreases HIV-1 NL4.3 viral replication in MT-4 cells and isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 2 and 9 nM, respectively).{45673}  

 

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SKU: 28439 - 5 mg Category:

Description

A CXCR4 antagonist (IC50 = 13 nM in a radioligand binding assay); selective for CXCR4 over CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2 (IC50s = >10 µM for all); reduces CXCL12-induced chemotaxis of CCRF-CEM T cells (IC50 = 19 nM); inhibits fusion of CHO-K1 cells expressing gp120 to P4 MAGI cells IC50 = 1.5 nM; decreases HIV-1 NL4.3 viral replication in MT-4 cells and isolated human PBMCs (IC50s = 2 and 9 nM, respectively)

Formal name: N1-(1H-benzimidazol-2-ylmethyl)-N1-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-1,4-butanediamine

Synonyms:  AMD 070|AMD 11070|X4P-001

Molecular weight: 349.5

CAS: 558447-26-0

Purity: ≥95%

Formulation: A crystalline solid

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