A potent and highly selective inhibitor of c-Kit (IC50 = 200 nM for human recombinant c-Kit)

Masitinib – 100 mg

Brand:
Cayman
CAS:
790299-79-5
Storage:
-20
UN-No:
Non-Hazardous - /

Masitinib is a potent and selective inhibitor of c-Kit (IC50 = 200 nM for human recombinant c-Kit), a receptor tyrosine kinase protein.{34061} It also inhibits PDGFRα and PDGFRβ (IC50s = 540 and 800 nM, respectively), and Lyn (IC50 = 510 nM). It has antiproliferative, antiangiogenic, and chemosensitizing properties.{34062}  

 

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Description

A potent and highly selective inhibitor of c-Kit (IC50 = 200 nM for human recombinant c-Kit), PDGFRα (IC50 = 540 nM), PDGFRβ (IC50 = 800 nM), and Lyn (IC50 = 510 nM)

Formal name: 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]-benzamide

Synonyms:  AB-1010

Molecular weight: 498.6

CAS: 790299-79-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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