A coumarin with anticancer activity; decreases proliferation and cell invasion induced by FBS in H1299 NSCLCs at 10 µM; decreases VEGF secretion in A549 and H1299 cells and inhibits capillary-like structure formation by HUVECs; decreases proliferation of U937 human leukemia cells (IC50 = 40 µM); reduces tumor growth in a U937 mouse xenograft model at 30 mg/kg

Marmesin – 10 mg

Brand:
Cayman
CAS:
13849-08-6
Storage:
-20
UN-No:
Non-Hazardous - /

Marmesin is a coumarin originally isolated from the mature bark of A. marmelos.{36707} Marmesin decreases proliferation and cell invasion induced by fetal bovine serum (FBS) in H1299 non-small cell lung cancer cells (NSCLCs) when used at a concentration of 10 µM.{36708} It decreases VEGF secretion in A549 and H1299 cells and inhibits capillary-like structure formation by human umbilical vein endothelial cells (HUVECs). Marmesin also decreases proliferation of U937 human leukemia cells (IC50 = 40 µM).{36709} It halts the cell cycle at the G2/M phase, increases the ratio of Bax to Bcl-2 protein, induces apoptosis, and inhibits cell migration. Marmesin reduces tumor growth in a U937 mouse xenograft model when administered at a dose of 30 mg/kg.  

 

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SKU: 25049 - 10 mg Category:

Description

A coumarin with anticancer activity; decreases proliferation and cell invasion induced by FBS in H1299 NSCLCs at 10 µM; decreases VEGF secretion in A549 and H1299 cells and inhibits capillary-like structure formation by HUVECs; decreases proliferation of U937 human leukemia cells (IC50 = 40 µM); reduces tumor growth in a U937 mouse xenograft model at 30 mg/kg

Formal name: (2S)-2,3-dihydro-2-(1-hydroxy-1-methylethyl)-7H-furo[3,2-g][1]benzopyran-7-one

Synonyms:  (+)-Marmesin|(S)-Marmesin|NSC 340840

Molecular weight: 246.3

CAS: 13849-08-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Coumarins||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis

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