An α1 Na+/K+ ATPase sodium pump inhibitor

Marinobufagenin – 5 mg

Brand:
Cayman
CAS:
470-42-8
Storage:
-20
UN-No:
Non-Hazardous - /

Marinobufagenin (MBG) is a bufadienolide steroid first isolated from toads of genus Bufo. It can also be excreted by mammalian cells, particularly kidney cells from hypertensive animals.{32977} MBG inhibits the ouabain-resistant α1 Na+/K+ ATPase subunit (IC50 = 78 nM), impairing a major sodium pump of the kidneys, resulting in natriuresis and arterial hypertension.{32977,32979} Serum and urine levels of MBG are also elevated after cardiac infarction, and a reduced form of MBG, marinobufotoxin, occurs in the plasma of patients with terminal renal failure.{32978,32979} Through its effects on the α1 Na+/K+ ATPase subunit, MBG has profound immediate and prolonged effects on kidney, heart, and vascular functions.{32979}  

 

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Description

An α1 Na+/K+ ATPase sodium pump inhibitor

Formal name: (3β,5β,15β)-14,15-epoxy-3,5-dihydroxy-bufa-20,22-dienolide

Synonyms:  Marinobufagin|MBG|NSC 234205

Molecular weight: 400.5

CAS: 470-42-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Kidney & Renal Disease

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