A 13R

Maresin 2 – 10 µg

Brand:
Cayman
CAS:
1639809-46-3
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Docosahexaenoic acid (DHA; Item No. 90310) is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.{18389,18390} Maresin 2 (MaR2) is a 13R,14S-dihydroxy DHA formed by recombinant human macrophage 12-lipoxygenase and soluble epoxide hydrolase co-incubated with DHA.{26522} At 1 ng/mouse, MaR2 was shown to reduce neutrophil infiltration by 40% in a mouse model of peritonitis, and at 10 pM, MaR2 can enhance human macrophage phagocytosis of zymosan A by 90%.{26522} Analytical and biological comparisons of synthetic MaR2 with endogenously derived MaR2 have confirmed its identity as matching the natural product.{14569}  

 

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Description

A 13R,14S-dihydroxy DHA formed by recombinant human macrophage 12-LO and sEH co-incubated with DHA; reduces neutrophil infiltration in a mouse model of peritonitis and enhances human macrophage phagocytosis of zymosan A

Formal name: 13R,14S-dihydroxy-4Z,7Z,9E,11E,16Z,19Z-docosahexaenoic acid

Synonyms:  13R,14S-diHDHA|13R,14S-dihydroxy Docosahexaenoic Acid|MaR2

Molecular weight: 360.5

CAS: 1639809-46-3

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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