A 7

Maresin 1 – 10 µg

Brand:
Cayman
CAS:
1268720-28-0
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Docosahexaenoic acid (DHA; Item No. 90310) is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.{18389,18390} Maresin 1 (7(R)-MaR1) is a 7,14-dihydroxy DHA formed from 14(S)-hydroperoxy DHA supplied exogenously to resident peritoneal mouse macrophages activated with zymosan A. It potently reduces infiltration of neutrophils into the mouse peritoneum in zymosan A-induced peritonitis when given intravenously (0.2 ng) and significantly increases phagocytosis of FITC-labeled zymosan A by isolated mouse macrophages (0.1-100 nM).{16640} Analytical and biological comparisons of synthetic 7(R)-MaR1 with endogenously derived 7(R)-MaR1 have confirmed its identity as matching the natural product.{14569}  

 

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SKU: 10878 - 10 µg Category:

Description

A 7,14-dihydroxy DHA formed from 14(S)-hydroperoxy DHA supplied exogenously to resident peritoneal mouse macrophages activated with zymosan A; reduces infiltration of neutrophils into the mouse peritoneum and increases phagocytosis of FITC-labeled zymosan A by macrophages

Formal name: 7R,14S-dihydroxy-4Z,8E,10E,12Z,16Z,19Z-docosahexaenoic acid

Synonyms:  7(R)-MaR1|7(R)-Maresin 1

Molecular weight: 360.5

CAS: 1268720-28-0

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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