An anthelmintic; has nematocidal activity against H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM); eliminates H. contortus

Marcfortine A – 5 mg

Brand:
Cayman
CAS:
75731-43-0
Storage:
-20
UN-No:
Non-Hazardous - /

Marcfortine A is an indole alkaloid originally isolated from P. roqueforti.{39450} It has nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM).{39451},{39453} Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively).{39453} It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.{39452}  

 

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SKU: 23486 - 5 mg Category:

Description

An anthelmintic; has nematocidal activity against H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM); eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively); dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing and muscle-type nAChRs, respectively

Formal name: (2’R,3’aS,9’aS,10’aS)-6′,7′,8′,9′,10′,10’a-hexahydro-1′,1′,4,4,12′-pentamethyl-spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,2′(3’H)-[1H,4H-3a,9a](iminomethano)cyclopenta[b]quinolizine]-9,11′(10H)-dione

Synonyms:  NSC 324645

Molecular weight: 477.6

CAS: 75731-43-0

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases

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