A xanthone glucoside with diverse biological activities; increases survival of HIV-1-infected MT-2 human leukemia cells (EC50 = 3.59 μg/ml); inhibits tumor growth and increases lifespan in an AFS mouse xenograft model at 10 μg/g; reduces TPA-induced production of H2O2 by mouse peritoneal macrophages ex vivo at 50 mg/kg; decreases TPA-induced DNA fragmentation in mouse liver and brain at 50 mg/kg; increases survival of γ-irradiated mice from 0.25-2 mg/kg; reduces fasting plasma glucose

Mangiferin – 1 g

Brand:
Cayman
CAS:
4773-96-0
Storage:
-20
UN-No:
Non-Hazardous - /

Mangiferin is a xanthone glucoside that has been found in M. indica with diverse biological activities.{37665} It increases survival of HIV-1-infected MT-2 human leukemia cells (EC50 = 3.59 μg/ml).{37662} In an ascitic fibrosarcoma (AFS) mouse xenograft model, mangiferin (10 μg/g) inhibits tumor growth by 47% at 15 days post inoculation and increases lifespan by 38% relative to control. Mangiferin (50 mg/kg, p.o.) reduces the production of hydrogen peroxide induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mouse peritoneal macrophages by 40% ex vivo.{37663} It also decreases TPA-induced DNA fragmentation in mouse liver and brain by 35 and 22%, respectively. Mangiferin (0.25-2 mg/kg, i.p.) dose-dependently increases survival of γ-irradiated mice.{37664} Mangiferin (10 mg/kg, i.p.) reduces fasting plasma glucose, total cholesterol, triglycerides, and LDL cholesterol (LDL-C) levels in a rat model of diabetes induced by streptozotocin (Item No. 13104) by 50, 57, 38.5, and 70%, respectively.{37665}  

 

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Description

A xanthone glucoside with diverse biological activities; increases survival of HIV-1-infected MT-2 human leukemia cells (EC50 = 3.59 μg/ml); inhibits tumor growth and increases lifespan in an AFS mouse xenograft model at 10 μg/g; reduces TPA-induced production of H2O2 by mouse peritoneal macrophages ex vivo at 50 mg/kg; decreases TPA-induced DNA fragmentation in mouse liver and brain at 50 mg/kg; increases survival of γ-irradiated mice from 0.25-2 mg/kg; reduces fasting plasma glucose, total cholesterol, triglycerides, and LDL-C levels in a rat model of streptozotocin-induced diabetes by 50, 57, 38.5, and 70%, respectively, at 10 mg/kg, i.p.

Formal name: 2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one

Synonyms:  NSC 248870

Molecular weight: 422.3

CAS: 4773-96-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Glycosides||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|DNA Damage and Repair||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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