A natural bicyclic pentapeptide that has antibacterial properties

Malformin C – 1 mg

Brand:
Cayman
CAS:
59926-78-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus.{33545} Malformin C potently blocks the ability of bleomycin (Item No. 13877) to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM).{33544} It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM).{33544} Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 µM, respectively) but has a low therapeutic index against cancer xenografts when tested in mice.{33546}  

 

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Description

A natural bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus; potently blocks bleomycin-induced G2 arrest in Jurkat cells (IC50 = 0.9 nM)

Formal name: cyclo(D-cysteinyl-D-cysteinyl-L-valyl-D-leucyl-L-leucyl), cyclic (1→2)-disulfide

Synonyms:  Malformin B1b

Molecular weight: 529.7

CAS: 59926-78-2

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics|Polypeptides||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Peptides||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Cycle|G2/S||Research Area|Cell Biology|Cell Cycle

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