A cyclopentapeptide fungal metabolite; a plant growth regulator that induces malformations in plant structure; inhibits replication of TMV (IC50s = 19.7 and 45.4 µg/ml

Malformin A – 500 µg

Brand:
Cayman
CAS:
3022-92-2
Storage:
-20
UN-No:
Non-Hazardous - /

Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities.{48222,48213,48214,48215,48216,48217} It is a plant growth regulator that induces malformations in plant structure.{48213} Malformin A inhibits replication of tobacco mosaic virus (TMV) in local lesion and leaf-disc assays (IC50s = 19.7 and 45.4 µg/ml, respectively).{48214} It is cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively), inhibits proliferation of PC3 and LNCaP cells (IC50s = 130 and 90 nM, respectively), and induces apoptosis and necrosis in PC3 and LNCaP cells.{48215,48216} Malformin A also increases the accumulation of reactive oxygen species, decreases the mitochondrial membrane potential, and induces autophagy in PC3 and LNCaP cells.{48216} It is toxic to mice when administered intraperitoneally (LD50 = 3.1 mg/kg) but not orally up to doses of 50 mg/kg.{48217}  

 

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Description

A cyclopentapeptide fungal metabolite; a plant growth regulator that induces malformations in plant structure; inhibits replication of TMV (IC50s = 19.7 and 45.4 µg/ml, respectively); cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively); inhibits proliferation of PC3 and LNCaP cells (IC50s = 130 and 90 nM, respectively); toxic to mice when administered intraperitoneally (LD50 = 3.1 mg/kg) but not orally up 50 mg/kg

Formal name: cyclo(D-cysteinyl-D-cysteinyl-L-valyl-D-leucyl-L-isoleucyl), cyclic (1→2)-disulfide

Synonyms:  Malformin A1

Molecular weight: 529.7

CAS: 3022-92-2

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Death|Necrosis||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Plant Biology|Plant Growth Regulators||Research Area|Toxicology

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