A diarylnonanoid with diverse biological activities; scavenges 59.9% of DPPH radicals at 7 μg/ml; active against S. aureus

Malabaricone C – 5 mg

Brand:
Cayman
CAS:
63335-25-1
Storage:
-20
UN-No:
Non-Hazardous - /

Malabaricone C is a diarylnonanoid that has been found in Myristica and has diverse biological activities.{45636,45637,45638,50203} It scavenges 59.9% of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals when used at a concentration of 7 μg/ml.{45636} Malabaricone C is active against S. aureus, B. subtilis, and C. albicans in vitro (MICs = 2-32 μg/ml).{45637} It is cytotoxic to A549, HL-60, and MCF-7 cells (IC50s = 12.3, 46.1, and 10.8 μM, respectively).{45638} Malabaricone C inhibits sphingomyelin synthase 1 (SMS1) and SMS2 activity in cell lysates (IC50s = 3 and 1.5 μM, respectively).{50203} It decreases body weight gain, hepatic steatosis, and hepatic and plasma triglyceride levels in a mouse model of high-fat diet-induced obesity when administered at a dose of 0.1% in the diet.  

 

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SKU: 29741 - 5 mg Category:

Description

A diarylnonanoid with diverse biological activities; scavenges 59.9% of DPPH radicals at 7 μg/ml; active against S. aureus, B. subtilis, and C. albicans in vitro (MICs = 2-32 μg/ml); cytotoxic to A549, HL-60, and MCF-7 cells (IC50s = 12.3, 46.1, and 10.8 μM, respectively); inhibits SMS1 and SMS2 activity in cell lysates (IC50s = 3 and 1.5 μM, respectively); decreases body weight gain, hepatic steatosis, and hepatic and plasma triglyceride levels in a mouse model of high-fat diet-induced obesity at 0.1% in the diet

Formal name: 1-(2,6-dihydroxyphenyl)-9-(3,4-dihydroxyphenyl)-1-nonanone

Synonyms:  NSC 287968

Molecular weight: 358.4

CAS: 63335-25-1

Purity: ≥98%

Formulation: A crystalline solid

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