A sulfonamide antibiotic; inhibits growth of clinical isolates of S. pyogenes

Mafenide – 500 mg

Brand:
Cayman
CAS:
138-39-6
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Mafenide is a sulfonamide antibiotic that inhibits growth of bacteria.{39511,39512} It inhibits growth of clinical isolates of S. pyogenes, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), Enterococcus, Enterobacteriaceae, and Gram-negative bacilli from burn patients in an agar well diffusion assay (mean zone of inhibition = 24-37 mm) but not in a broth dilution assay with MIC values ranging from 250 to greater than 5,000 μg/ml.{39511} Mafenide also inhibits growth of clinical isolates of K. pneumoniae that produce extended spectrum β-lactamase (ESBL), P. aeruginosa, and A. baumannii-calcoaceticus from burn patients in an agar well diffusion assay (mean zones of inhibition = 23.5, 28.9, and 25.8 mm, respectively) but not in a broth dilution assay (mean MICs = 1,024 μg/ml, 1,024 μg/ml, and 1,024 μg/ml, respectively).{39512} It decreases mortality in a rat model of burn wounds seeded with rat virulent P. aeruginosa.{39513} Mafenide also inhibits human carbonic anhydrase (CA) I and II (Kis = 41.91 and 0.612 μM, respectively).{39514} Formulations containing mafenide have been used in the treatment of severe burns.  

 

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Description

A sulfonamide antibiotic; inhibits growth of clinical isolates of S. pyogenes, MSSA, MRSA, Enterococcus, Enterobacteriaceae, and Gram-negative bacilli from burn patients in an agar well diffusion assay (mean zone of inhibition = 24-37 mm); inhibits growth of clinical isolates of K. pneumoniae that produce ESBL, P. aeruginosa, and A. baumannii-calcoaceticus from burn patients in an agar well diffusion assay (mean zones of inhibition = 23.5, 28.9, and 25.8 mm, respectively); decreases mortality in a rat model of burn wounds seeded with rat virulent P. aeruginosa

Formal name: 4-(aminomethyl)-benzenesulfonamide

Synonyms:  NSC 34632

Molecular weight: 186.2

CAS: 138-39-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Sulfonamides||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia

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