A fungal metabolite; inhibits adhesion of HL-60 human leukemia cells to HUVECS; inhibits the growth of SKOV3 ovarian cancer cells; inhibits the growth of Gram-positive bacteria

(+)-Macrosphelide A – 5 mg

Brand:
Cayman
CAS:
172923-77-2
Storage:
-20
UN-No:
Non-Hazardous - /

(+)-Macrosphelide A is a fungal metabolite originally isolated from Microsphaeropsis.{47293} It inhibits adhesion of HL-60 human leukemia cells to human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner. It also inhibits the growth of SKOV3 ovarian cancer cells in a concentration-dependent manner.{47294} (+)-Macrosphelide A inhibits the growth of Gram-positive bacteria, including B. subtilis, M. luteus, B. thuringiensis, and S. aureus (MICs = 143, 143, 57, and 57 μg/ml, respectively), but not Gram-negative bacteria or fungi.{47295}  

 

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SKU: 27704 - 5 mg Category:

Description

A fungal metabolite; inhibits adhesion of HL-60 human leukemia cells to HUVECS; inhibits the growth of SKOV3 ovarian cancer cells; inhibits the growth of Gram-positive bacteria, including B. subtilis, M. luteus, B. thuringiensis, and S. aureus (MICs = 143, 143, 57, and 57 μg/ml, respectively)

Formal name: 9R,15R-dihydroxy-4S,10S,16S-trimethyl-1,5,11-trioxacyclohexadeca-7E,13E-diene-2,6,12-trione

Synonyms: 

Molecular weight: 342.3

CAS: 172923-77-2

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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