A β2-adrenergic receptor agonist; induces relaxation of isolated tracheal muscle in guinea pigs and inhibits bronchoconstriction in a guinea pig model of experimental asthma; decreases blood pressure and increases heart rate in a dose-dependent manner in rats

Mabuterol – 5 mg

Brand:
Cayman
CAS:
56341-08-3
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Mabuterol is an agonist of the β2-adrenergic receptor (β2-AR).{36154,36155,36156} It induces relaxation of isolated tracheal muscle in guinea pigs and inhibits bronchoconstriction in a guinea pig model of experimental asthma.{36155} Administration of mabuterol decreases blood pressure and increases heart rate in a dose-dependent manner in rats, cats, and dogs.{36156} These effects are reversed by the selective β2-AR antagonist ICI 118551 (Item No. 15591), indicating mabuterol is acting at β2-ARs.{36154} At concentrations ≥1 μM, mabuterol acts as a β1-AR antagonist in isolated dog right atria.  

 

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SKU: 23246 - 5 mg Category:

Description

A β2-adrenergic receptor agonist; induces relaxation of isolated tracheal muscle in guinea pigs and inhibits bronchoconstriction in a guinea pig model of experimental asthma; decreases blood pressure and increases heart rate in a dose-dependent manner in rats, cats, and dogs; acts as a β1-AR antagonist in isolated dog right atria at concentrations ≥1 μM

Formal name: 4-amino-3-chloro-α-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)-benzenemethanol

Synonyms: 

Molecular weight: 310.7

CAS: 56341-08-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart|Arrhythmia

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