A norepinephrine analogue with anticancer activity; inhibits cell growth in a panel of human and mouse cancer cell lines at 20 µg/ml; reduces clonogenic survival of L1210 leukemia cells; increases survival in N1E155 and L1210 mouse xenograft models at 40 and 20 mg/kg

m-Iodobenzylguanidine (hemisulfate) – 10 mg

Brand:
Cayman
CAS:
87862-25-7
Storage:
-20
UN-No:
Non-Hazardous - /

m-Iodobenzylguanidine (MIBG) is an analogue of norepinephrine with anticancer activity.{42768} It inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines when used at a concentration of 20 µg/ml and reduces clonogenic survival of L1210 leukemia cells in a concentration-dependent manner. MIBG increases survival in N1E155 and L1210 mouse xenograft models when administered at doses of 40 and 20 mg/kg, respectively. It selectively accumulates in chromaffin tissues and tumors and formulations containing radiolabeled forms of MIBG have been used as imaging agents in the diagnosis and treatment of neuroendocrine tumors.{42769} MIBG also inhibits ADP-ribose linkage to membrane proteins in turkey erythrocyte membranes.  

 

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SKU: 19998 - Category:

Description

A norepinephrine analogue with anticancer activity; inhibits cell growth in a panel of human and mouse cancer cell lines at 20 µg/ml; reduces clonogenic survival of L1210 leukemia cells; increases survival in N1E155 and L1210 mouse xenograft models at 40 and 20 mg/kg, respectively; selectively accumulates in chromaffin tissues and tumors; inhibits ADP-ribose linkage to membrane proteins in turkey erythrocyte membranes,

Formal name: N-[(3-iodophenyl)methyl]-guanidine, hemisulfate

Synonyms:  meta-Iodobenzylguanidine|MIBG

Molecular weight: 324.1

CAS: 87862-25-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death

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