A mixture of lysophosphatidylcholines isolated from egg; a major phospholipid component of oxidized low-density lipoprotein (ox-LDL)

Lysophosphatidylcholines (egg) – 10 mg

Brand:
Cayman
CAS:
9008-30-4
Storage:
-20
UN-No:
Non-Hazardous - /

Lysophosphatidylcholines are produced by hydrolysis of the fatty acid of phosphatidylcholine (PC; Item Nos. 24343 | 24370) at either the sn-1 or sn-2 position by phospholipase A2 (PLA2) or by lecithin-cholesterol acyltranferase (LCAT), which transfers the fatty acid to cholesterol.{24384} Lysophosphatidylcholine has effects on a variety of cell types, including smooth muscle cells, endothelial cells, T lymphocytes, monocytes, and macrophages among others. It is a major phospholipid component of oxidized low-density lipoprotein (ox-LDL), and it accumulates in animal models of atherosclerosis. Lysophosphatidylcholine also has pro-inflammatory properties through its activation and modulation of various signaling pathways, including the ERK pathway as well as through protein tyrosine kinase and G protein-coupled receptor (GPCR) signal transduction. It is released from apoptotic cells in vitro following caspase-3 activation of the calcium-independent PLA2 and acts as a chemoattractant for monocytes.{37411} Lysophosphatidylcholine (2 µl, 1%) injected into the caudal cerebellar peduncle of rats induces demyelination of axons in vivo, which are extensively remyelinated by oligodendrocytes six weeks following injection.{37412} Lysophosphatidylcholines (egg) is a mixture of lysophosphatidylcholines isolated from chicken egg that has a fatty acid of variable chain length acylated to the sn-1 or sn-2 position. [Matreya, LLC. Catalog No. 1046]  

 

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SKU: 24331 - 10 mg Category:

Description

A mixture of lysophosphatidylcholines isolated from egg; a major phospholipid component of oxidized low-density lipoprotein (ox-LDL), and it accumulates in animal models of atherosclerosis; pro-inflammatory; released from apoptosis cells in vitro and and acts as a chemoattractant for monocytes; induces demyelination of axons in vivo in rats (2 µl, 1%)

Formal name:

Synonyms:  ​Lyso-Lecithins (egg)

Molecular weight: 495.6

CAS: 9008-30-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Glycerophospholipids||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Lipid Biochemistry|Glycerophospholipids||Research Area|Neuroscience

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