An LSD1 inhibitor; inhibits LSD1 activity by 85.9% at 10 µM; increases the level of H3K4 methylation in HCT116 cells; induces re-expression of SFRP1

Lysine-specific Demethylase Inhibitor (1C) (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1234494-75-7
Storage:
-20
UN-No:
Non-Hazardous - /

Lysine-specific demethylase inhibitor (1C) (LSD inhibitor (1C)) is an inhibitor of LSD1, a repressive demethylase selective for histone H3 lysine 4 (H3K4).{18521,16614} LSD inhibitor (1C) inhibits LSD1 activity by 85.9% when used at a concentration of 10 µM.{18521} It increases the level of H3K4 methylation, including H3K4me1 and H3K4me2 but not H3K9me2 levels, in HCT116 human colon carcinoma cells.{16614} LSD inhibitor (1C) also induces re-expression of the Wnt signaling pathway proteins secreted frizzle-related protein 1 (SFRP1), SFRP4, and SFRP5, as well as the transcription factor GATA5, which are aberrantly silenced in HCT116 cells.  

 

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Description

An LSD1 inhibitor; inhibits LSD1 activity by 85.9% at 10 µM; increases the level of H3K4 methylation in HCT116 cells; induces re-expression of SFRP1, SFRP4, and SFRP5, as well as the transcription factor GATA5, in HCT116 cells,,

Formal name: N1,N1,N15,N15-tetramethyl-2,6,10,14-tetraazapentadecanediimidamide, tetrahydrochloride

Synonyms:  KDM1 Inhibitor I|LSD Inhibitor I

Molecular weight: 474.3

CAS: 1234494-75-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Research Area|Epigenetics, Transcription, & Translation

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