An inhibitor of autophagy; induces p62 accumulation and increases the ratio of LC3-II to LC3-I in C8161 melanoma cells in a concentration-dependent manner; increases the number of autophagic vesicles per cell in tumors in a C8161 mouse xenograft model and reduces tumor volume and growth in a 1205Lu melanoma mouse xenograft model at 76 mg/kg; reduces tumor growth rate

Lys05 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
1391426-24-6
Storage:
-20
UN-No:
Non-Hazardous - /

Lys05 is an inhibitor of autophagy.{51043} It induces p62 accumulation and increases the ratio of LC3-II to LC3-I in C8161 melanoma cells in a concentration-dependent manner. Lys05 (76 mg/kg) increases the number of autophagic vesicles per cell in tumors in a C8161 mouse xenograft model and reduces tumor volume and growth in a 1205Lu melanoma mouse xenograft model. It also reduces tumor growth rate, volume, and weight in an HT-29 colon cancer mouse xenograft model when administered at doses greater than or equal to 10 mg/kg but increases bowel thickness and obstruction when administered at 80 mg/kg.  

 

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SKU: 27334 - 10 mg Category:

Description

An inhibitor of autophagy; induces p62 accumulation and increases the ratio of LC3-II to LC3-I in C8161 melanoma cells in a concentration-dependent manner; increases the number of autophagic vesicles per cell in tumors in a C8161 mouse xenograft model and reduces tumor volume and growth in a 1205Lu melanoma mouse xenograft model at 76 mg/kg; reduces tumor growth rate, volume, and weight in an HT-29 colon cancer mouse xenograft model at ≥10 mg/kg but increases bowel thickness and obstruction at 80 mg/kg

Formal name: N2-(7-chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)amino]ethyl]-N1-methyl-1,2-ethanediamine, trihydrochloride

Synonyms:  Lys01

Molecular weight: 549.8

CAS: 1391426-24-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Autophagy||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy

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