An activator of ULK1 (EC50 = 18.94 nM); increases Beclin 1

LYN-1604 – 10 mg

Brand:
Cayman
CAS:
2088939-99-3
Storage:
-20
UN-No:
De Minimis - 3077 / 9

LYN-1604 is an activator of unc-51-like kinase 1 (ULK1; EC50 = 18.94 nM).{36916} It increases Beclin 1, LC3-II, and total LC3 protein levels and reduces levels of p62 in human MDA-MB-231 triple-negative breast cancer (TNBC) cells in a concentration-dependent manner, indicating an increase in autophagy. It also increases the cleavage of the pro-apoptotic protein caspase-3. LYN-1604 decreases the viability of MDA-MB-231 cells in vitro (IC50 = 1.66 μM), an effect that can be reversed by the autophagy inhibitor 3-methyladenine (3-MA; Item No. 13242). LYN-1604 (25, 50, and 100 mg/kg) reduces tumor growth in an MDA-MB-231 mouse xenograft model.  

 

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SKU: 24007 - 10 mg Category:

Description

An activator of ULK1 (EC50 = 18.94 nM); increases Beclin 1, LC3-II, and total LC3 protein levels and reduces levels of p62 in human MDA-MB-231 TNBC cells in a concentration-dependent manner, indicating an increase in autophagy; increases the cleavage of the pro-apoptotic protein caspase-3; decreases the viability of MDA-MB-231 cells in vitro (IC50 = 1.66 μM); reduces tumor growth in an MDA-MB-231 mouse xenograft model at 25, 50, and 100 mg/kg

Formal name: 2-[bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]-ethanone

Synonyms: 

Molecular weight: 584.6

CAS: 2088939-99-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy

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