A cell-permeable γ-secretase inhibitor (IC50 = 0.14 nM) that has been shown to block Notch activation in vitro at 500 µM; induces apoptosis in Kaposi’s sarcoma cells

LY411575 – 10 mg

Brand:
Cayman
CAS:
209984-57-6
Storage:
-20
UN-No:
Non-Hazardous - /

γ-Secretase is a multi-subunit aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. One well-known substrate of this enzyme is Notch, a transmembrane receptor that plays a key role in cell fate decisions including cell proliferation, differentiation, and apoptosis. LY411575 is a cell-permeable γ-secretase inhibitor (IC50 = 0.14 nM) that has been shown to block Notch activation in vitro at 500 µM.{26489,26490} LY411575 can induce apoptosis in Kaposi’s sarcoma cells as well as promote intestinal goblet cell differentiation in a mouse model of colitis.{26490,26491} It has also been observed to promote neural differentiation of mouse embryonic stem cells.{26492}  

 

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Description

A cell-permeable γ-secretase inhibitor (IC50 = 0.14 nM) that has been shown to block Notch activation in vitro at 500 µM; induces apoptosis in Kaposi’s sarcoma cells, promotes intestinal goblet cell differentiation in a mouse model of colitis, and promotes neural differentiation of mouse embryonic stem cells

Formal name: N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-αS-hydroxy-benzeneacetamide

Synonyms: 

Molecular weight: 479.5

CAS: 209984-57-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Cell Signaling|Notch Signaling||Research Area|Cell Biology|Proteolysis|Lysosomal Proteases||Research Area|Cell Biology|Stem Cell Research|Differentiation

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