Description
A 5-HT1F receptor agonist (Ki = 6 nM); selective for 5-HT1F over 5-HT1A-E , 5-HT2A-C, and 5-HT7 receptors (Kis = 0.53-4.85 µM), as well as dopamine D1 and D2, GABAA, histamine H1, muscarinic, and α1-, α2-, and β-adrenergic receptors (Kis = 3.69->100 µM); inhibits forskolin-stimulated cAMP accumulation in L-M(TK-) cells expressing recombinant human 5-HT1F receptors (EC50 = 3 nM); decreases electrically stimulated extravasation of plasma proteins in the dura mater in a rat trigeminal nerve model of migraine headache (ID50s = 0.6 and 2.1 ng/kg for i.v. and oral administration, respectively)
Formal name: N-[(3R)-3-(dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluoro-benzamide, monohydrochloride
Synonyms:
Molecular weight: 387.9
CAS: 1217756-94-9
Purity: ≥98%
Formulation: A solid
