A 5-HT1F receptor agonist (Kd =0.446 nM); selective for 5-HT1F over other G protein-coupled 5-HT receptor subtypes (Kis = 16.4->3

LY334370 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
199673-74-0
Storage:
-20
UN-No:
Non-Hazardous - /

LY334370 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1F (Kd = 0.446 nM).{52208} It is selective for 5-HT1F over other G protein-coupled 5-HT receptor subtypes with Ki values ranging from 16.4 to greater than 3,000 nM in radioligand binding assays. LY334370 inhibits forskolin-induced cAMP accumulation in mouse L-M(TK-) cell membranes expressing the recombinant human 5-HT1F receptor (EC50 = 1.51 nM).{52209} It decreases electrically stimulated extravasation of plasma proteins in the dura mater in a guinea pig trigeminal nerve model of migraine headache.  

 

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SKU: 29481 - 5 mg Category:

Description

A 5-HT1F receptor agonist (Kd =0.446 nM); selective for 5-HT1F over other G protein-coupled 5-HT receptor subtypes (Kis = 16.4->3,000 nM); inhibits forskolin-induced cAMP accumulation in mouse L-M(TK-) cell membranes expressing the recombinant human 5-HT1F receptor (EC50 = 1.51 nM); decreases electrically stimulated extravasation of plasma proteins in the dura mater in a guinea pig trigeminal nerve model of migraine headache.

Formal name: 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]-benzamide, monohydrochloride

Synonyms: 

Molecular weight: 387.9

CAS: 199673-74-0

Purity: ≥98%

Formulation: A crystalline solid

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