A selective and potent inhibitor of PKCβ1 and PKCβ2 (IC50 = 4.7 and 5.9 nM

LY333531 (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
169939-93-9
Storage:
-20
UN-No:
Non-Hazardous - /

The protein kinase C (PKC) isoforms PKCβ1 and PKCβ2 have central roles in cell signaling in diabetes, diffuse large B-cell lymphoma, and cardiovascular diseases.{21723,21721,21722,21725} LY333531 is a selective and potent inhibitor of PKCβ1 and PKCβ2 (IC50 = 4.7 and 5.9 nM, respectively).{21724} For comparison, its IC50 values for PKC isoforms α, γ, δ, ε, ζ, and η are 360, 300, 250, 600, >100,000, and 52 nM, respectively.{21724} LY333531 is effective in vivo.{21723,21721}  

 

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Description

A selective and potent inhibitor of PKCβ1 and PKCβ2 (IC50 = 4.7 and 5.9 nM, respectively) that is effective in vivo

Formal name: (9S)-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione, monohydrochloride

Synonyms:  Ruboxistaurin

Molecular weight: 505

CAS: 169939-93-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling

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