A 5-HT1D antagonist; selective over 5-HT1B

LY310762 – 5 mg

Brand:
Cayman
CAS:
192927-92-7
Storage:
-20
UN-No:
Non-Hazardous - /

LY310762 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT1D (Ki = 249 nM for guinea pig receptors).{40403} It is selective for 5-HT1D over the 5-HT1B receptor, where it inhibits binding of radiolabeled citalopram by only 32% when used at a concentration of 1,000 nM. LY310762 potentiates 5-HT (Item No. 14332) release stimulated by potassium in guinea pig cortex (EC50 = 31 nM). It also reverses vasodilation induced by 5-HT in rat kidney perfused by phenylephrine (Item Nos. 17205 | 18619) when administered at a dose of 1 mg/kg.{40402}  

 

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SKU: 22938 - 5 mg Category:

Description

A 5-HT1D antagonist; selective over 5-HT1B, where it inhibits binding of radiolabeled citalopram by only 32% at a concentration of 1,000 nM; potentiates 5-HT release stimulated by potassium in guinea pig cortex (EC50 = 31 nM); reverses vasodilation induced by 5-HT in phenylephrine-perfused rat kidney when administered at a dose of 1 mg/kg

Formal name: 1-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-one, monohydrochloride

Synonyms: 

Molecular weight: 430.9

CAS: 192927-92-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Vasculature|Vasoconstriction||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease

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