An inhibitor of mTOR-dependent phosphorylation of S6K; reduces cell proliferation in human lung epithelial adenocarcinoma cells

LY303511 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
854127-90-5
Storage:
-20
UN-No:
Non-Hazardous - /

LY303511 is a close structural analog of LY294002 (Item No. 70920), a selective phosphatidylinositol 3-kinase (PI3K) inhibitor.{32629} LY303511, however, does not inhibit PI3K-dependent phosphorylation of Akt but instead has been shown to inhibit mTOR-dependent phosphorylation of S6K.{32629} It can reduce cell proliferation in human lung epithelial adenocarcinoma cells, blocking G2/M progression and inhibiting casein kinase 2 activity.{32629} LY303511 demonstrates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitizing activity in HeLa cells that are refractory to TRAIL-induced apoptosis.{32630} LY303511 is also reported to block voltage-gated potassium (Kv) channels.{32631}  

 

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Description

An inhibitor of mTOR-dependent phosphorylation of S6K; reduces cell proliferation in human lung epithelial adenocarcinoma cells, blocking G2/M progression and inhibiting CK2 activity

Formal name: 8-phenyl-2-(1-piperazinyl)-4H-1-benzopyran-4-one, dihydrochloride

Synonyms: 

Molecular weight: 379.3

CAS: 854127-90-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Kinase Inhibitors|mTOR||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|Casein Kinase Signaling||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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