A potent RARγ antagonist (Ki = 1.1 nM); selective for RARγ over RARα and RARβ (Kis = >1

LY2955303 – 10 mg

Brand:
Cayman
CAS:
1433497-19-8
Storage:
-20
UN-No:
Non-Hazardous - /

LY2955303 is a potent antagonist of retinoic acid receptor γ (RARγ; Ki = 1.1 nM).{42717} It is selective for RARγ over RARα and RARβ (Kis = >1,700 and >2,980 nM, respectively). LY2955303 reduces differential weight bearing between the contralateral and ipsilateral limbs in a rat model of monoiodoacetate-induced osteoarthritis (ED50 = 0.72 mg/kg).  

 

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SKU: 25833 - 10 mg Category:

Description

A potent RARγ antagonist (Ki = 1.1 nM); selective for RARγ over RARα and RARβ (Kis = >1,700 and >2,980 nM, respectively); reduces differential weight bearing between the contralateral and ipsilateral limbs in a rat model of monoiodoacetate-induced osteoarthritis (ED50 = 0.72 mg/kg) ,

Formal name: 4-[5-[3,5-bis(1,1-dimethylethyl)phenyl]-1-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-1H-pyrazol-3-yl]-benzoic acid

Synonyms: 

Molecular weight: 578.7

CAS: 1433497-19-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Neuroscience|Pain Research

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