An antitumor agent that binds to the human Smo receptor and inhibits Shh-induced Gli1 expression (IC50 = ~2.4 nM in vitro)

LY2940680 – 5 mg

Brand:
Cayman
CAS:
1258861-20-9
Storage:
-20
UN-No:
Non-Hazardous - /

Smoothened (Smo) is a GPCR-like receptor that, with Patched, mediates hedgehog (Hh) signaling to regulate gene expression through the Gli transcription factors.{21774} LY2940680 is an antitumor agent that binds to the human Smo receptor and inhibits Sonic Hh-induced Gli1 expression (IC50 = ~2.4 nM in vitro).{27679,27681,27680} The potential anticancer activity of LY2940680 is currently under clinical investigation.  

 

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Description

An antitumor agent that binds to the human Smo receptor and inhibits Shh-induced Gli1 expression (IC50 = ~2.4 nM in vitro)

Formal name: 4-fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)-benzamide

Synonyms:  Taladegib

Molecular weight: 512.5

CAS: 1258861-20-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Cell Signaling|Hedgehog Signaling||Research Area|Cell Biology|Cell Signaling|Hedgehog Signaling

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