A selective inhibitor of IKK2 (IC50 = 30 nM); suppresses constitutively activated NF-κB and induces apoptosis in lymphoma cells both in vitro and in preclinical mouse models of B and T cell lymphoma

LY2409881 – 5 mg

Brand:
Cayman
CAS:
946518-60-1
Storage:
-20
UN-No:
De Minimis - 3077 / 9

LY2409881 is a selective inhibitor of IκB kinase β (IKK2; IC50 = 30 nM).{32487} It inhibits IKK1 and other common kinases at ≥10-fold higher concentrations.{32487} LY2409881 has been shown to suppress constitutively activated NF-κB and to induce apoptosis in lymphoma cells both in vitro and in preclinical mouse models of B and T cell lymphoma both as a single agent and in combination with histone deacetylase inhibitors.{32487}  

 

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Description

A selective inhibitor of IKK2 (IC50 = 30 nM); suppresses constitutively activated NF-κB and induces apoptosis in lymphoma cells both in vitro and in preclinical mouse models of B and T cell lymphoma

Formal name: 2-[5-chloro-2-[[3-(4-methyl-1-piperazinyl)propyl]amino]-4-pyrimidinyl]-N-cyclopropyl-benzo[b]thiophene-4-carboxamide, trihydrochloride

Synonyms: 

Molecular weight: 594.4

CAS: 946518-60-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|IKKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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