A small molecule inhibitor of the TGF-β receptor type 1 kinase (IC50 = 56 nM) that has been used to study the role of TGF-β signaling in triple negative breast cancer cells and hepatocellular carcinoma cells

LY2157299 – 5 mg

Brand:
Cayman
CAS:
700874-72-2
Storage:
-20
UN-No:
Non-Hazardous - /

LY2157299 is a small molecule inhibitor of the TGF-β receptor type 1 kinase (IC50 = 56 nM).{24957} It has been used to study the role of TGF-β signaling in chemotherapy-induced expansion of cancer stem-like cells in triple negative breast cancer cell lines and xenografts.{24958} LY2157299 has also been shown to inhibit the migration and tumor growth of hepatocellular carcinoma cell lines by disrupting Smad-2 phosphorylation.{24959}  

 

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Description

A small molecule inhibitor of the TGF-β receptor type 1 kinase (IC50 = 56 nM) that has been used to study the role of TGF-β signaling in triple negative breast cancer cells and hepatocellular carcinoma cells

Formal name: 4-[5,6-dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide

Synonyms:  Galunisertib

Molecular weight: 369.4

CAS: 700874-72-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Activin-like Kinases (ALKs)||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cancer Stem Cell Research|Proliferation||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling

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