A small molecule inhibitor of the TGF-β receptor type 1/type II kinases (IC50 = 69 nM); used to study the role of TGF-β signaling in tumor cell migration and metastasis; disrupts Smad-2 phosphorylation

LY2109761 – 5 mg

Brand:
Cayman
CAS:
700874-71-1
Storage:
-20
UN-No:
Non-Hazardous - /

LY2157299 is a small molecule inhibitor of the TGF-β receptor type 1/type II kinases (IC50 = 69 nM).{25084} It has been used to study the role of TGF-β signaling in tumor cell migration and metastasis in pancreatic tumor cell lines where 5 μM of the compound completely disrupts Smad-2 phosphorylation, an immediate downstream target of the kinase activity.{25082} It can also suppress radiation-induced inflammatory cytokine signaling and proangiogenic genes, including ID1, in human primary fibrobalsts.{25083}  

 

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Description

A small molecule inhibitor of the TGF-β receptor type 1/type II kinases (IC50 = 69 nM); used to study the role of TGF-β signaling in tumor cell migration and metastasis; disrupts Smad-2 phosphorylation, an immediate downstream target of the kinase activity

Formal name: 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]-quinoline

Synonyms: 

Molecular weight: 441.5

CAS: 700874-71-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Activin-like Kinases (ALKs)||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling

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