A cyclic depsipeptide antibiotic that displays antitumor activity; acts as a bifunctional DNA intercalator that strongly binds DNA and forms crosslinks between DNA molecules; inhibits reverse transcriptases from HIV-1 and HIV-2 (IC50s = 7 and 68 nM

Luzopeptin A – 1 mg

Brand:
Cayman
CAS:
75580-37-9
Storage:
-20
UN-No:
Non-Hazardous - /

Luzopeptin A is a cyclic depsipeptide antibiotic first isolated from an actinomycete strain.{29678,29676} It displays antitumor activity, as it is highly active in mice against a variety of experimental tumors.{29678} Luzopeptin A acts as a bifunctional DNA intercalator that strongly binds DNA and forms crosslinks between DNA molecules.{29675} It also inhibits reverse transcriptases from HIV-1 and HIV-2 (IC50s = 7 and 68 nM, respectively), as well as cellular DNA polymerases.{29677,29679}  

 

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Description

A cyclic depsipeptide antibiotic that displays antitumor activity; acts as a bifunctional DNA intercalator that strongly binds DNA and forms crosslinks between DNA molecules; inhibits reverse transcriptases from HIV-1 and HIV-2 (IC50s = 7 and 68 nM, respectively), as well as cellular DNA polymerases

Formal name: Luzopeptin A

Synonyms:  BBM-928A

Molecular weight: 1,427.40

CAS: 75580-37-9

Purity: ≥99%

Formulation: A tan solid

Product Type|Biochemicals|Antivirals|Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Reverse Transcriptases||Research Area|Cancer|DNA Damage and Repair|DNA Intercalating Agents||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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