Description
A beta-acid; active against B. subtilis and S. aureus (MICs = 1 and 1.2 µg/ml, respectively), and T. b. brucei and L. m. mexicana (IC50s = 0.9 and 4.7 µg/ml, respectively); scavenges DPPH radicals in a cell-free assay and inhibits lipid peroxidation in rat brain homogenates (IC50s = 25 and 39 µM, respectively); reduces proliferation, cell migration, and capillary tube formation in HUVECs at 2.5 to 50 µg/ml; lupulone (40 µg/ml) activates the extrinsic apoptotic death pathway in SW480 and SW620 colon cancer cells.
Formal name: 3,5-dihydroxy-2,6,6-tris(3-methyl-2-buten-1-yl)-4-(3-methyl-1-oxobutyl)-2,4-cyclohexadien-1-one
Synonyms:
Molecular weight: 414.6
CAS: 468-28-0
Purity: ≥95%
Formulation: A solid