A beta-acid; active against B. subtilis and S. aureus (MICs = 1 and 1.2 µg/ml

Lupulone – 1 mg

Brand:
Cayman
CAS:
468-28-0
Storage:
-20
UN-No:
Non-Hazardous - /

Lupulone is a beta-acid that has been found in the hop plant, H. lupulus, and has diverse biological activities, including antibacterial, antioxidant, and anticarcinogenic properties.{45412,45413,45416} Lupulone is active against B. subtilis and S. aureus (MICs = 1 and 1.2 µg/ml, respectively), as well as T. b. brucei and L. m. mexicana (IC50s = 0.9 and 4.7 µg/ml, respectively).{45412,45413} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay and inhibits lipid peroxidation in rat brain homogenates (IC50s = 25 and 39 µM, respectively).{45414} It reduces proliferation, migration, and capillary tube formation in human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 2.5 to 50 µg/ml.{45415} Lupulone (40 µg/ml) activates the extrinsic apoptotic death pathway in SW480 and SW620 colon cancer cells.{45416}  

 

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SKU: 28481 - 1 mg Category:

Description

A beta-acid; active against B. subtilis and S. aureus (MICs = 1 and 1.2 µg/ml, respectively), and T. b. brucei and L. m. mexicana (IC50s = 0.9 and 4.7 µg/ml, respectively); scavenges DPPH radicals in a cell-free assay and inhibits lipid peroxidation in rat brain homogenates (IC50s = 25 and 39 µM, respectively); reduces proliferation, cell migration, and capillary tube formation in HUVECs at 2.5 to 50 µg/ml; lupulone (40 µg/ml) activates the extrinsic apoptotic death pathway in SW480 and SW620 colon cancer cells.

Formal name: 3,5-dihydroxy-2,6,6-tris(3-methyl-2-buten-1-yl)-4-(3-methyl-1-oxobutyl)-2,4-cyclohexadien-1-one

Synonyms: 

Molecular weight: 414.6

CAS: 468-28-0

Purity: ≥95%

Formulation: A solid

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