Description
A selective inhibitor of COX-2 over COX-1 (IC50s = 0.13 and 67 µM, respectively); reduces increases in the levels of PGE2 induced by IL-1β in human dermal fibroblasts (IC50 = 0.14 µM), as well as in LPS-stimulated RAW 264.7 cells at 1-100 µM; decreases LPS-induced increases in the levels of PGE2 in a rat model of air pouch inflammation at 3 and 10 mg/kg; reduces M. tuberculosis-induced increases in hind paw volume and the radiological and histopathological severity of arthritic lesions in a rat model of chronic arthritis at 2 mg/kg
Formal name: 2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-benzeneacetic acid
Synonyms: COX 189
Molecular weight: 293.7
CAS: 220991-20-8
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity
