A natural sesterterpenoid which reversibly inhibits sPLA2 isoforms from bee venom (IC50 = 230 nM) and snake venom

Luffariellolide – 1 mg

Brand:
Cayman
CAS:
111149-87-2
Storage:
-20
UN-No:
Non-Hazardous - /

Luffariellolide is a natural sesterterpenoid which reversibly inhibits secretory phospholipase A2 isoforms from bee venom (IC50 = 230 nM) and snake venom, reducing inflammation.{23775} It blocks the production of platelet-activating factor in stimulated neutrophils (IC50 = 5 μM).{23770} Luffariellolide is also a structural mimic of all-trans retinoic acid (RA) and, at 1 μM, acts as an agonist for the RA receptors RAR α, β, and γ but not for other nuclear receptors.{23773} In RA-sensitive cancer cell lines, luffariellolide induces the expression of RAR target genes and inhibits cell growth.{23773} It also inhibits the activation of hypoxia-inducible factor by hypoxia (IC50 = 3.6 μM).{23774}  

 

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Description

A natural sesterterpenoid which reversibly inhibits sPLA2 isoforms from bee venom (IC50 = 230 nM) and snake venom, reducing inflammation; at 1 μM, acts as an agonist for RAR α, β, and γ but not for other nuclear receptors; inhibits the activation of HIF-1 by hypoxia (IC50 = 3.6 μM)

Formal name: 4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadien-1-yl]-5-hydroxy-2(5H)-furanone

Synonyms: 

Molecular weight: 386.6

CAS: 111149-87-2

Purity: ≥98%

Formulation: An oil

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Research Area|Endocrinology & Metabolism|Hormones & Receptors|RARs, RORs, & RXRs||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Glycerophospholipids|Phospholipases

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