A partial agonist of GPR109A/HCA2 receptors (Ki = 0.55 μM in a radioligand binding assay); stimulates [35S]-GTPγS binding and increases phosphorylation of ERK in HEK293T cells expressing GPR109A/HCA2 receptors (EC50s = 3.1 and 0.32 μM

LUF6283 – 10 mg

Brand:
Cayman
CAS:
92933-48-7
Storage:
-20
UN-No:
Non-Hazardous - /

LUF6283 is a partial agonist of GPR109A/HCA2 G protein-coupled receptors (Ki = 0.55 μM in a radioligand binding assay).{42585} It stimulates [35S]-GTPγS binding and increases phosphorylation of ERK in HEK293T cells expressing GPR109A/HCA2 receptors (EC50s = 3.1 and 0.32 μM, respectively). In vivo, LUF6283 (400 mg/kg per day) reduces plasma levels of VLDL and hepatic expression of apolipoprotein B in mice.  

 

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Description

A partial agonist of GPR109A/HCA2 receptors (Ki = 0.55 μM in a radioligand binding assay); stimulates [35S]-GTPγS binding and increases phosphorylation of ERK in HEK293T cells expressing GPR109A/HCA2 receptors (EC50s = 3.1 and 0.32 μM, respectively); reduces plasma levels of VLDL and hepatic expression of apolipoprotein B in mice at 400 mg/kg per day ,

Formal name: 5-butyl-1H-pyrazole-3-carboxylic acid

Synonyms: 

Molecular weight: 168.2

CAS: 92933-48-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins

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