A positive allosteric modulator of mGluR4 (EC50 = 500 nM for the human receptor in a FLIPR assay); selective for mGluR4 over mGluR6 (EC50 = 7 μM) and a panel of 73 CNS ion channels

Lu AF21934 – 1 mg

Brand:
Cayman
CAS:
1445605-23-1
Storage:
-20
UN-No:
Non-Hazardous - /

Lu AF21934 is a positive allosteric modulator (PAM) of metabotropic glutamate receptor 4 (mGluR4; EC50 = 500 nM for the human receptor in a FLIPR assay).{48374} It is selective for mGluR4 over mGluR6 (EC50 = 7 μM) and a panel of 73 CNS ion channels, G protein-coupled receptors (GPCRs), and enzymes at 10 μM. Lu AF21934 (12 mg/kg) reduces marble burying behavior and stress-induced hyperthermia in mice, indicating anxiolytic-like activity, but also reduces locomotor activity. It inhibits MK-801- and amphetamine-induced hyperactivity in mice and prevents MK-801-induced decreases in social interaction in rats.{48375} Lu AF21934 (0.5 and 2.5 mg/kg) also reduces harmaline-induced hyperactivity, but not tremor, in rats.{48376}  

 

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SKU: 27045 - 1 mg Category:

Description

A positive allosteric modulator of mGluR4 (EC50 = 500 nM for the human receptor in a FLIPR assay); selective for mGluR4 over mGluR6 (EC50 = 7 μM) and a panel of 73 CNS ion channels, GPCRs, and enzymes at 10 μM; reduces marble burying behavior and stress-induced hyperthermia in mice at 12 mg/kg but also reduces locomotor activity; inhibits MK-801- and amphetamine-induced hyperactivity in mice; prevents MK-801-induced decreases in social interaction in rats; reduces harmaline-induced hyperactivity in rats at 0.5 and 2.5 mg/kg

Formal name: N1-(3,4-dichlorophenyl)-1S,2R-cyclohexanedicarboxamide

Synonyms: 

Molecular weight: 315.2

CAS: 1445605-23-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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