A 5-HT6 receptor antagonist (Ki = 0.83 nM); selective for 5-HT6 over other 5-HT receptor subtypes (Kis = 250 to >10

LU AE58054 – 250 mg

Brand:
Cayman
CAS:
467459-31-0
Storage:
-20
UN-No:
Non-Hazardous - /

LU AE58054 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 0.83 nM).{48420} It is selective for 5-HT6 over other 5-HT receptor subtypes (Kis = 250 to >10,000 nM) and 70 other targets but does bind to α1A- and α1B-adrenergic receptors (α1B-ARs; Kis = 21 and 22 nM, respectively). LU AE58054 (5-20 mg/kg) reverses phencyclidine-induced deficits in novel object recognition memory in rats. When administered in combination with the cholinesterase inhibitor rivastigmine (Item No. 14270), LU AE58054 has an additive effect on the decreased number of slips and falls made by rats with bilateral striatal-dopaminergic and cortical-cholinergic system lesions, a model of Parkinson’s disease motor disruption, in the Michigan complex motor control task.{48421}  

 

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SKU: 27335 - 250 mg Category:

Description

A 5-HT6 receptor antagonist (Ki = 0.83 nM); selective for 5-HT6 over other 5-HT receptor subtypes (Kis = 250 to >10,000 nM) and 70 other targets but does bind to α1A- and α1B-ARs (Kis = 21 and 22 nM, respectively); reverses phencyclidine-induced deficits in novel object recognition memory in rats at 5-20 mg/kg; has an additive effect on the decreased number of slips and falls made by rats in a dual-lesion model of Parkinson’s disease motor disruption when administered in combination with rivastigmine

Formal name: 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]-1H-indole-3-ethanamine

Synonyms: 

Molecular weight: 398.4

CAS: 467459-31-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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